Phytochemical Screening and Evaluation of the Anti-Salmonella Activity of Leaf Extracts of Telfairia occidentalis Hook. F. (Cucurbitaceae) on Salmonella typhii Cell Culture

Typhoid fever, a bacterial infection caused by Salmonella typhi whose treatment is use of antibiotics. And the these antibiotics associated with drug resistance, high cost medication and less accessibility to rural populations remains an issue concern. The aim this research was indentify bioactive metabolites leaf T. occidentalis determine anti-salmonella activity. antibacterial activity extracts (aqueous maceration, decoction, infusion ethanol maceration) Telfairia (Fluted pumpkin or gourd) on typhi, determined using agar well diffusion technique investigate its potential as anti-bacterial agent. phyto-chemical constituents, Minimum Inhibitory Concentration (MIC) Bactericidal (MBC) analyzed. phytochemical analysis showed presence saponins, flavonoids, tannins, phenolics coumarin absence phlobatanins oxalates. decoction leaves demonstrated highest against S. (15+/-2.7mm) at 1000mg/ml. MIC for aqueous infusion, recorded 62.5mg/ml that maceration 15.625mg/ml. Due extraordinarily concentration extract needed produce activity, study's findings imply has negligible Salmonella.